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Large
waistline may increase colon cancer risk
Study: Adults with fat stomachs more prone to abnormal cell
growth
Updated: 5:41 p.m. ET July 5, 2006
Adults who carry much of their fat around the middle may
be at increased risk of colon cancer, a large European study
suggests.
Researchers found that among nearly 370,000 adults from
nine European countries, men and women with large waistlines
were more likely to develop colon cancer than those who
were trimmer around the middle.
Waist size and waist-to-hip ratio, which are both indicators
of abdominal obesity, appeared more important in colon cancer
risk than does overall weight. In fact, the study found
that body mass index (BMI) — a measure of weight in relation
to height — was unrelated to colon cancer risk among the
women.
The findings, reported in Wednesday’s issue of the Journal
of the National Cancer Institute, suggest that abdominal
fat holds a particular influence over colon cancer risk.
People with large waistlines often have a high amount of
fat around the abdominal organs, and this type of fat is
more “metabolically active,” explained Dr. Tobias Pischon,
a researcher at the German Institute of Human Nutrition
in Potsdam-Rehbruecke and the lead author of the study.
Hormones may affect cancer cells
It’s possible, he told Reuters Health, that this visceral
fat increases colon cancer risk by raising levels of certain
hormones that affect cell growth, including the growth of
cancer cells. For example, the researcher noted, people
with type 2 diabetes have a higher rate of colon cancer
— supporting a potential role for the hormones insulin and
insulin-like growth factor 1 in promoting tumor cell growth.
Whatever the reason, the new findings point to the importance
of preventing abdominal obesity in particular, according
to Pischon.
The findings come from a large ongoing study of nutrition
and cancer risk among European adults. The researchers included
368,277 men and women who had their weight and body measurements
taken and who completed questionnaires on diet, exercise
and other lifestyle factors at
the start of the study.
Women have higher risk
Over the next six years, the researchers found that adults
with larger midlines were more likely to develop colon cancer.
Compared with the slimmest men, those with the largest waistlines
were 39 percent more likely to be diagnosed with the cancer;
women with the most fat around the middle had a 48-percent
higher risk of the disease than those with the smallest
waistlines.
BMI was linked to colon cancer risk among men only.
Previous studies have found the same sex difference when
it comes to BMI and colon cancer risk, according to Pischon’s
team. One reason, they note, may be the differences in body
fat distribution between men and women.
When a man has a high BMI, it’s typically because of fat
around the middle. Women, on the other hand, often carry
much of their fat around the hips and thighs.
So waist size may be a more accurate predictor of colon
cancer risk than overall BMI, particularly for women, according
to Pischon.
“Our study shows that it’s more important to keep an eye
on the waist circumference, especially in women,” he said.
Copyright 2006 Reuters Limited. All rights reserved. Republication
or redistribution of Reuters content is expressly prohibited
without the prior written consent of Reuters.
http://www.msnbc.msn.com/
id/13719343/
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