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Cause and Prevention of Testicular Cancer
Researchers study patterns of cancer in the population to
discover whether some people are more likely than others
to get certain cancers. If they can learn what causes the
disease, they may be able to suggest ways to prevent it.
Although any man can get testicular cancer, the disease
is rare. It accounts for only about 1 percent of all cancers
in American men. Although most other cancers affect mostly
older people, testicular cancer usually occurs in young
men. It is more common in white men than in black.
We know that testicular cancer is not contagious. No one
can "catch" it from another person. However, doctors
do not know exactly what causes this disease. They can seldom
explain why one person gets it while another doesn't, but
research does show that some men are more likely to develop
testicular cancer. For example, the risk is higher than
average for boys born with their testicles in the lower
abdomen rather than in the scrotum. The cancer risk for
boys with this condition (called undescended testicles or
cryptorchidism) is increased if the problem is not corrected
in early childhood. Research has also shown that testicular
cancer is sometimes linked to certain other rare conditions
in which the testicles do not develop normally.
Some men whose mothers took a hormone called DES (diethylstilbestrol)
during pregnancy to prevent miscarriage have testicular
abnormalities. But scientists do not know whether prenatal
exposure to DES (or any other female hormone) increases
the risk of testicular cancer.
Some patients with testicular cancer have a history of injury
to the scrotum. But no one knows whether such an injury
can actually cause cancer. Many doctors think such an injury
simply calls attention to a tumor that was already growing.
Detection and Diagnosis
Every man can help himself by doing testicular self-examination
(TSE) every month, by getting regular checkups that include
a testicular exam, and by seeing a doctor promptly if he
notices any symptoms of testicular disease.
Researchers are looking for additional tumor markers that
may be present in abnormal amounts in the blood or urine
of a person with very early testicular cancer. If such markers
are found, it might be possible to detect testicular cancer
even before any symptoms are noticed. Several such markers
have been studied, and research is continuing.
Treatment of Testicular Cancer
Researchers are looking for treatment methods that are more
effective and easier for patients to tolerate. They are
studying new drugs and drug combinations, varied doses,
and different treatment schedules.
When research shows that a new treatment method has promise,
the method is used to treat cancer patients in clinical
trials. These trials are designed to answer scientific questions
and find out whether a new approach is both safe and effective.
Patients who take part in research make an important contribution
to medical science and may have the first chance to benefit
from improved treatment methods.
Patients with testicular cancer are encouraged to consider
participating in a trial and should discuss this option
with their doctor. The National Cancer Institute booklet,
What Are Clinical Trials All About? is for patients who
may be interested in taking part in clinical research.
One way to learn about clinical trials is through Physician
Data Query (PDQ), a computerized resource of cancer treatment
information. Developed by the National Cancer Institute,
PDQ contains an up-to-date list of trials all over the country.
Doctors can obtain an access code and use a personal computer
to get PDQ information, or they can use the services of
a medical library. Also, the Cancer Information Service,
at 1-800-4-CANCER (1-800-422-6237), can provide PDQ information
to doctors, patients, and the public.
There is much yet to learn about what causes testicular
cancer and how it might be prevented. Our understanding
is growing, and as new knowledge is gained, we hope that
fewer men will develop the disease. At the same time, better
methods of detection and treatment already have contributed
to greatly increased survival rates for men with testicular
cancer. The remarkable improvements in dealing with this
disease may, in fact, lead the way in other types of cancer.
Information provided by the
National Institutes of Health
http://healthlink.mcw.edu/
article/946011724.html
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